Membrane driven flasks for high density cell culture. The flasks are designed to enhance small scale bio-production for antibody and protein generation. Conventional in vivo or in vitro cell culture methods can be laborious, may have low cell density and require significant purification. CELLine™ flasks address these 3 areas of limitation observed in static tissue culture flasks.
How does the CELLine™ flask work?
Media compartment: this compartment allows for bulk storage of cell culture growth medium. This reduces the media refreshing requirement significantly as the media compartment is 50 times the size of the cell compartment.
Metabolite regulating upper membrane: the upper dialysis membrane has a 10 kDa cut off limit. This regulates the flow of metabolites to and from the cell compartment and retains all proteins in the cell compartment.
Cell compartment: the cell compartment provides the ideal area to inoculate and achieve high density cultures. The compartment concentrates cells, their products, and limits the requirement for any exogenous growth factors.
Gas permeable lower membrane: with static cultures, gas transfer rates can be the limiting factor in high density cultures. The CELLine™ flask places the cells directly against the gas permeable membrane to achieve optimal levels of oxygen and carbon dioxide.
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